Mark Cuban describes the pharmaceutical industry as the easiest business he has ever disrupted, aiming to lower prices through his company Cost Plus Drugs. By eliminating middle layers that increase prescription costs, the medications are priced up to 90% lower than traditional retail. The model features no insurance requirements, no hidden markups, and full price transparency, with plans to extend direct contracting rates to hospitals and providers. Small changes in this $500 billion industry can lead to significant impacts.